ros kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TMS1743	Salvigenin		MAO , Autophagy , ROS Kinase
	Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.		MAO , Autophagy , ROS Kinase
T21482	Uniconazole		P450 , ROS Kinase
	Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM). CYP707As is a major ABA catabolic enzyme that catabolize Abscisic acid, accordingly suppress gibberellin and sterol biosynthesis.		P450 , ROS Kinase
T11254	F-1		ROS , ALK , ROS Kinase
	F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathwa...		ROS , ALK , ROS Kinase
T4071	Repotrectinib	TPX-0005,TPX 0005,TPX0005	Trk receptor , ROS , Src , ALK , ROS Kinase
	Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.		Trk receptor , ROS , Src , ALK , ROS Kinase
T1661	Crizotinib	PF-02341066	c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
	Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.		c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
T3455	Merestinib	LY2801653	Discoidin Domain Receptor (DDR) , FLT , c-Met/HGFR , ROS , ROS Kinase
	Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosph...
T9192	BIIB068		BTK
	BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.		BTK
T3678	Entrectinib	RXDX-101,NMS-E628	Trk receptor , ROS , ALK , Autophagy , ROS Kinase
	Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini...		Trk receptor , ROS , ALK , Autophagy , ROS Kinase
T3061	Lorlatinib	PF-6463922,PF-06463922,Loratinib	Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
	Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.		Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
T8399	Crizotinib hydrochloride	PF-02341066 hydrochloride	c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
	Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)		c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
T22318	Taletrectinib	DS-6051b,AB-106	Trk receptor , ROS , ROS Kinase
	Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.		Trk receptor , ROS , ROS Kinase
T0860L	Mefloquine	Ro215998,WR 142490,Ro-215998,Lariam,Ro 215998	Others
	Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic l...		Others
T3604	Sodium dichloroacetate	Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)	Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...		Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
T22553	Adaphostin	1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410	Bcr-Abl
	Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.		Bcr-Abl
T2028	NG 52	NG52,NG-52,Compound 52	CDK
	NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.		CDK
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T60220	ROS kinases-IN-1		ROS Kinase
	ROS kinases-IN-1 is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity.		ROS Kinase
T74671	ROS kinases-IN-2		ROS Kinase
	ROS kinases-IN-2 is a potent ROS kinase inhibitor with an inhibition rate of 21.53% measured at 10 μM.ROS kinases-IN-2 has potential anticancer activity and can be used to study abnormal cell growth.		ROS Kinase
T1962	ASP3026	ASP 3026	Apoptosis , ALK
	ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.		Apoptosis , ALK
T15362	FX-11	LDHA Inhibitor FX11	Dehydrogenase
	FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce...		Dehydrogenase